This study discusses the computation and comparison of the dose distribution around various Gold plaque ophthalmic applicators using Monte Carlo method. The dosimetry of ophthalmic plaques of sizes 12 and 14 mm diameter designed to hold either Ir-192 or I-125 is computed using Monte Carlo code, MCNP. The sources of different configurations are introduced in plaque and the Monte Carlo computed dosimetry is compared with the reported experimental values for two different radioisotopes such as Ir-192 and I-125. Study indicates that suitable source and plaque dimension may be selected depending on the size of the tumor. From this study, it is concluded that for small tumors of sizes less than 1 cm, I-125 may be preferred and for tumors of sizes greater than 1 cm Ir-192 may be used
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